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Hypertension-specific association of cardio-ankle vascular index with subclinical left ventricular function in a

Xue Zhang1, Yibo Li1, Xinyue Wang1

  • 1Department of Cardiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|April 2, 2024
PubMed

Insights

The cardio-ankle vascular index (CAVI) is linked to poorer diastolic heart function. This association is more pronounced for subclinical systolic dysfunction in patients with hypertension.

Area of Science:

  • Cardiovascular research
  • Vascular health
  • Hypertension management

Background:

  • Subclinical cardiac dysfunction is a precursor to overt heart failure.
  • The cardio-ankle vascular index (CAVI) is a measure of arterial stiffness.
  • The relationship between CAVI and subclinical cardiac dysfunction, particularly in hypertensive individuals, requires further elucidation.

Purpose of the Study:

  • To investigate the association between CAVI and subclinical cardiac dysfunction.
  • To compare these associations in hypertensive patients versus normotensive subjects.

Main Methods:

  • 1887 subjects from Danyang were enrolled (2018-2019).
  • CAVI was measured using the VaSera VS-1500A device.
  • Echocardiography assessed ejection fraction (EF), E/A, mitral annular early diastolic velocities (e'), and left ventricular (LV) global longitudinal strain (GLS).

Main Results:

  • Higher CAVI tertiles correlated with increased LV mass index and E/e', and decreased GLS, E/A, and e' velocity (P < .001).
  • Adjusted analyses confirmed decreased GLS, E/A, and e' with increasing CAVI tertiles (P ≤ .04).
  • Increased CAVI was associated with a higher risk of subclinical LV systolic dysfunction in hypertensive patients (OR = 2.61; P = .005).

Conclusions:

  • Elevated CAVI is associated with impaired subclinical diastolic function.
  • The link between CAVI and subclinical systolic dysfunction is more significant in hypertensive individuals.

Keywords:
cardio‐ankle vascular indexechocardiographye’global longitudinal strainhypertension

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