Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Schistocytes in erythroleukemia.

J N Atkins, H B Muss

    The American Journal of the Medical Sciences
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Erythroleukemia can mimic microangiopathic hemolytic anemia (MAHA) with characteristic red blood cell changes, even without visible blasts in peripheral blood smears. Bone marrow examination is crucial for diagnosing MAHA and excluding myelodysplastic syndromes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Association of self-directed walking with toxicity moderation during chemotherapy for the treatment of early breast cancer.

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2023
    Same author

    Patient-reported treatment toxicity and adverse events in Black and White women receiving chemotherapy for early breast cancer.

    Breast cancer research and treatment·2021
    Same author

    Myosteatosis evaluation using erector spinae and psoas muscles to predict adverse events during adjuvant chemotherapy for breast cancer.

    Breast cancer research and treatment·2021
    Same author

    The association of body composition parameters and adverse events in women receiving chemotherapy for early breast cancer.

    Breast cancer research and treatment·2020
    Same author

    Association of body composition with function in women with early breast cancer.

    Breast cancer research and treatment·2020
    Same author

    Myosteatosis and prognosis in cancer: Systematic review and meta-analysis.

    Critical reviews in oncology/hematology·2019
    Same journal

    Providers' Perspectives on Hospital-Based Tobacco Treatment Efforts.

    The American journal of the medical sciences·2026
    Same journal

    In Memoriam: Maurice A. Mufson, MD, MACP.

    The American journal of the medical sciences·2026
    Same journal

    Outcomes of Acute Myeloid Leukemia Patients Admitted to the Intensive Care Unit within 100 days of Allogeneic Hematopoietic Stem Cell Transplantation.

    The American journal of the medical sciences·2026
    Same journal

    Association Between Reverse Triiodothyronine and Cardiac Complications in Patients with Uncontrolled Graves' Disease.

    The American journal of the medical sciences·2026
    Same journal

    Chlorthalidone vs. hydrochlorothiazide in hypertension management: Lessons for guiding clinical practice.

    The American journal of the medical sciences·2026
    Same journal

    The impact of COVID-19 on alcohol-associated hepatitis and alcohol-associated cirrhosis.

    The American journal of the medical sciences·2026
    See all related articles

    Area of Science:

    • Hematology
    • Oncology

    Background:

    • Microangiopathic hemolytic anemia (MAHA) is a condition characterized by the destruction of red blood cells within small blood vessels.
    • Erythroleukemia, also known as DiGuglielmo's syndrome, is a rare type of leukemia.

    Observation:

    • A retrospective review of 12 erythroleukemia patients' peripheral blood morphology was conducted.
    • Patients exhibited significant red blood cell abnormalities, including anisocytosis, poikilocytosis, macrocytosis, nucleated red cells, helmet cells, fragmented red cells, and elliptocytosis.
    • Notably, schistocytes, a hallmark of MAHA, were observed in these patients.

    Findings:

    • Erythroleukemia can present with peripheral blood findings indistinguishable from MAHA.
    • Six out of 12 patients lacked peripheral blasts, and thrombocytopenia was common, further complicating diagnosis.

    Related Experiment Videos

  • The study identified RBC changes typical of MAHA in erythroleukemia patients, challenging previous assumptions.

    • Implications:

    • Patients with suspected MAHA require bone marrow examination to rule out underlying conditions like erythroleukemia or myelodysplastic syndromes.
    • This highlights the importance of comprehensive hematologic evaluation beyond peripheral smear analysis.
    • Accurate diagnosis is critical for appropriate treatment and management of these hematologic malignancies.