Related Experiment Video
Updated: Jun 29, 2025
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
17.3K
Pregnancy and the Autoimmune Patient
Brooke S Mills1, Bonnie L Bermas2
1University of Texas Southwestern Medical Center, 2001 Inwood Road, Dallas, TX, 75390, USA.
Current Allergy and Asthma Reports
|April 2, 2024
Summary
Pregnancy dynamically alters immunity, potentially impacting autoimmune and inflammatory rheumatic diseases (AIRDs). Optimal outcomes require pre-conception planning and managing AIRDs with compatible medications throughout pregnancy.
Area of Science:
- Immunology
- Rheumatology
- Obstetrics
Background:
- Pregnancy involves complex immunological changes.
- Autoimmune and inflammatory rheumatic diseases (AIRDs) can be affected by pregnancy.
- Previously, the impact of pregnancy on AIRD activity was underestimated.
Purpose of the Study:
- To review current knowledge of immunologic changes during pregnancy.
- To discuss the effect of pregnancy on AIRD activity.
- To highlight recent management strategies for autoimmune patients during pregnancy.
Main Methods:
- Literature review of immunologic changes in pregnancy.
- Analysis of disease activity in autoimmune patients during gestation.
- Evaluation of pre-conception and pregnancy management data.
Main Results:
- Pregnancy is an immunologically dynamic state affecting AIRDs.
- A significant number of patients experience active AIRDs during pregnancy.
- Uncontrolled inflammatory diseases are linked to adverse pregnancy outcomes like preeclampsia and prematurity.
Conclusions:
- Pre-conception counseling and planning are crucial for disease control.
- Managing AIRDs with pregnancy-compatible medications is essential.
- Optimal pregnancy outcomes depend on adequate disease control before, during, and after pregnancy.
Related Concept Videos
01:29Autoimmune Disorders
430
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
430
01:22Development of Immunocompetence
306
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
306
01:15Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:19Psychoneuroimmunology: Diabetes and Cancer
28
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
28
01:38What is the Immune System?
111.2K
Overview
111.2K