Universal Transitions between Growth and Dormancy via Intermediate Complex Formation.
Jumpei F Yamagishi1, Kunihiko Kaneko2,3
1Department of Basic Science, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Physical Review Letters
|April 2, 2024
Summary
This study models simple cell growth, revealing that nutrient depletion causes a transition to dormancy due to accumulating complexes. This jamming effect leads to hysteresis and delayed recovery in reaction networks.
Area of Science:
- Biophysics
- Systems Biology
- Chemical Kinetics
Background:
- Cellular growth dynamics are crucial for understanding biological systems.
- Nutrient availability significantly impacts cell proliferation and dormancy.
- Complex reaction networks underlie cellular processes.
Purpose of the Study:
- To numerically investigate a simple cell model with catalytic reactions and intermediate complex formation.
- To elucidate the mechanisms driving the transition from exponential growth to dormancy.
- To analyze the phenomena of hysteresis and lag time in growth recovery.
Main Methods:
- Numerical simulation of a catalytic reaction network model.
- Analysis of intermediate complex accumulation and its impact on reaction jamming.
- Dynamical systems analysis of corresponding mean-field models.
Main Results:
- Observed a transition from exponential growth to a growth-arrested dormant phase upon nutrient depletion.
- Identified accumulation of intermediate complexes as the cause of reaction jamming.
- Demonstrated hysteresis and lag time for growth recovery.
- Showcased component diversification during the transition.
Conclusions:
- The studied cell model exhibits generic properties of random reaction networks.
- Intermediate complex accumulation is a key factor in regulating cell growth phases.
- Hysteresis and dormancy are emergent properties of complex catalytic networks.
More Related Videos
10:39Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II
Published on: February 26, 2018
15.5K
07:25Combining Histochemical Staining and Image Analysis to Quantify Starch in the Ovary Primordia of Sweet Cherry during Winter Dormancy
Published on: March 20, 2019
6.2K
Related Concept Videos
01:45Positive Regulator Molecules
106.1K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
106.1K
02:36Cells Coordinate Growth and Proliferation
4.5K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.5K
00:50Anaphase Promoting Complex
2.9K
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
2.9K
01:28The Cell Cycle Control System
2.9K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
2.9K
01:10Zygotic Development And Stem Cell Formation
5.2K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.2K
01:28Maturation of Endosomes
4.2K
The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
4.2K