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Updated: Jun 29, 2025

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Published on: June 12, 2021
Disease-State Understanding and Experience of Patients Receiving Continuous Intravenous Inotropic Support as
Mansi Maini1, Kelley M Anderson2, Matthew Seplowe3
1Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA.
Patients with advanced heart failure receiving continuous intravenous inotropic support (CIIS) report improved quality of life. However, many expect CIIS to increase longevity, which contradicts evidence, highlighting a need for better prognostic awareness.
Area of Science:
- Cardiology
- Palliative Care
- Patient Outcomes
Background:
- Continuous intravenous inotropic support (CIIS) is increasingly used for advanced heart failure (HF).
- CIIS can improve functional class but does not extend survival.
- Understanding patient perceptions of CIIS is crucial for goal-concordant care.
Purpose of the Study:
- To assess patient understanding of CIIS therapeutic intent.
- To evaluate prognostic awareness in patients receiving CIIS.
- To examine quality of life (QoL) and treatment satisfaction in advanced HF patients on CIIS.
Main Methods:
- Prospective, cross-sectional, multicenter study.
- Survey administered via telephone to 48 outpatients on CIIS in the US (2020-2022).
- Descriptive and inferential statistics used for data analysis.
Main Results:
- Most patients expected CIIS to improve well-being (79%) and longevity (75%), but not cure HF (19%).
- Overall QoL was rated as somewhat better (46%) or significantly better (35%).
- High treatment satisfaction reported (87% at least somewhat satisfied).
Conclusions:
- Patients on palliative CIIS report enhanced QoL and high satisfaction.
- Patient expectations of increased survival with CIIS are misaligned with current evidence.
- Further research is needed to improve prognostic awareness and ensure goal-concordant care.
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