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Relationship between prognostic nutritional index and post-stroke cognitive impairment
Yongchun Wang1,2, Guimei Zhang1,2, Yanxin Shen1,2
1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Nutritional Neuroscience
|April 2, 2024
Summary
A low Prognostic Nutritional Index (PNI) is linked to post-stroke cognitive impairment (PSCI). This simple index may help identify patients at higher risk for cognitive decline after a stroke.
Area of Science:
- Neurology
- Nutritional Science
- Biomarkers
Background:
- The Prognostic Nutritional Index (PNI) is a recognized prognostic tool in various diseases.
- Its role in post-stroke cognitive impairment (PSCI) is not well-established.
- Physicians are interested in PNI as a potential diagnostic index.
Purpose of the Study:
- To investigate the association between the Prognostic Nutritional Index (PNI) and post-stroke cognitive impairment (PSCI).
- To determine if PNI can serve as a screening indicator for PSCI risk.
Main Methods:
- 285 acute ischemic stroke patients were analyzed.
- PNI calculated using serum albumin and lymphocyte count.
- PSCI defined by Mini-Mental State Examination (MMSE) scores < 27 at follow-up.
- Logistic and linear regression models used to assess associations.
Main Results:
- Low PNI was independently associated with PSCI (OR: 2.158, 95% CI: 1.205-3.863).
- PNI scores correlated with MMSE and attention domain scores.
- PNI improved predictive model discrimination for PSCI.
Conclusions:
- Low PNI is an independent risk factor for PSCI.
- PNI scores are specifically linked to global cognition and attention deficits.
- PNI is a promising, simple indicator for identifying individuals at risk of PSCI due to impaired immune-nutritional status.
