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Related Experiment Videos

Plasma fibronectin in various hemopathic diseases.

J de Russé, P Colombat, X Lavoix

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |January 15, 1985
    PubMed
    Summary

    Human plasma fibronectin levels increase with age in healthy individuals. Decreased fibronectin is observed in various hemopathic diseases, suggesting prognostic value in cancer evolution.

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    Area of Science:

    • Biochemistry
    • Hematology
    • Immunology

    Background:

    • Plasma fibronectin is a glycoprotein involved in various biological processes.
    • Age and hematological conditions can influence plasma fibronectin levels.

    Purpose of the Study:

    • To investigate the impact of age on plasma fibronectin in healthy individuals.
    • To assess plasma fibronectin levels in patients with hemopathic diseases.
    • To determine the prognostic significance of fibronectin in malignant hemopathies.

    Main Methods:

    • Laser nephelometric immunoassay was used to quantify plasma fibronectin.
    • Healthy subjects were stratified into three age groups.
    • Hemopathic patients were analyzed without infection or therapy.

    Main Results:

    • Plasma fibronectin levels significantly increase with age in healthy populations.
    • Decreased fibronectin levels were observed in acute myeloblastic leukemia, polycythemia vera, osteomyelofibrosis, Waldenström disease, benign dysproteinemia, refractory anemia, and stage IV non-Hodgkin lymphoma.
    • Lower fibronectin levels were particularly noted in transfused patients with acute myeloblastic leukemia.

    Conclusions:

    • Age is a significant factor influencing plasma fibronectin concentrations.
    • Reduced plasma fibronectin is a marker for several hemopathic diseases.
    • Plasma fibronectin levels may hold prognostic value in the progression of malignant hemopathies.

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