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Pleiotropy, epistasis and the genetic architecture of quantitative traits

Trudy F C Mackay1,2, Robert R H Anholt3,4

  • 1Center for Human Genetics, Clemson University, Greenwood, SC, USA. tmackay@clemson.edu.

Nature Reviews. Genetics
|April 2, 2024
PubMed

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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