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A Comprehensive Review on Nanoparticles as Drug Delivery System and Their Role for Management of Hypertension

Prerna1, Dinesh Chandra Bhatt2, Khalid Basir Mir3

  • 1Department of Pharmaceutics, MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University) Mullana, Ambala, 133207, Haryana, India.

Current Pharmaceutical Biotechnology
|April 3, 2024
PubMed

Insights

Hypertension management faces challenges with traditional drugs. Oral nanoparticulate systems offer improved bioavailability and reduced side effects for better hypertension treatment.

Area of Science:

  • Cardiovascular Medicine
  • Nanotechnology
  • Pharmacology

Background:

  • Hypertension is a major risk factor for severe cardiovascular diseases like stroke and heart failure.
  • Conventional antihypertensive medications have limitations including poor bioavailability, frequent dosing, and side effects.
  • Nanocarriers and nanoformulations show potential to enhance drug delivery and reduce toxicity.

Purpose of the Study:

  • To review the challenges associated with traditional antihypertensive formulations.
  • To highlight the potential of oral nanoparticulate systems in managing hypertension.
  • To discuss the role of chronotherapeutics in hypertension treatment.

Main Methods:

  • Literature review of existing studies on hypertension, drug delivery systems, and chronotherapeutics.
  • Analysis of the benefits of nanocarriers for drug bioavailability and toxicity reduction.
  • Exploration of the circadian patterns of blood pressure in relation to treatment strategies.

Main Results:

  • Traditional antihypertensive formulations often suffer from suboptimal bioavailability and significant side effects.
  • Nanoparticulate systems can improve drug bioavailability, reduce dosing frequency, and minimize toxicity.
  • Chronotherapeutics are crucial for managing hypertension due to its circadian nature.

Conclusions:

  • Oral nanoparticulate systems present a promising solution to overcome the limitations of conventional antihypertensive drugs.
  • Integrating nanotechnology with chronotherapeutics can significantly improve hypertension management.
  • Further research into nanoformulations is essential for developing more effective hypertension therapies.

Keywords:
Polymeric nanoparticlesapplications.dendrimersdrug delivery systemshypertensionliposomesnano-emulsions

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