Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liwen Liu1,2, Yu Chen2, Tao Zhang3

  • 1Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 3, 2024
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strong Oxide-Support Interaction (SOSI): Engineering Interfacial Microenvironments for Advanced Catalysis.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

KIAA1429 promotes gallbladder cancer progression through m6A-dependent post-transcriptional modification of KIF20A.

Scientific reports·2026
Same author

Privacy-Preserving Virtual Contrast-enhanced MRI for Nasopharyngeal Carcinoma: A Multi-center Study.

International journal of radiation oncology, biology, physics·2026
Same author

Central Asian vegetation is more sensitive to soil moisture drought than to heat and meteorological drought.

Journal of environmental management·2026
Same author

Roseburia intestinalis-derived extracellular vesicles alleviate osteoporosis through gut microbiota-regulated histidylleucine via Akt/FOXO1 signaling.

Communications biology·2026
Same author

Discovery of selenium-containing amino acid derivatives as novel ENL YEATS domain inhibitors via AlphaScreen-based high throughput screening.

Bioorganic chemistry·2026

Y-box-binding protein 1 (YBX1) promotes esophageal squamous cell carcinoma (ESCC) progression by stabilizing spermine oxidase (SMOX) mRNA in an m5C-dependent manner, offering a potential therapeutic target for ESCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • 5-methylcytosine (m5C) modifications are implicated in tumor initiation and progression.
  • The role of Y-box-binding protein 1 (YBX1) in esophageal squamous cell carcinoma (ESCC) is not well understood.

Purpose of the Study:

  • To investigate the role and mechanism of YBX1 in ESCC progression.
  • To identify potential therapeutic targets for ESCC.

Main Methods:

  • Gain- and loss-of-function assays in ESCC cells.
  • RNA immunoprecipitation sequencing (RIP-seq) and m5C methylated RNA immunoprecipitation and sequencing (MeRIP-seq).
  • Analysis of the mTORC1 signaling pathway.

Main Results:

Keywords:
5‐methylcytosineESCCSMOXYBX1metastasis

Related Experiment Videos

  • YBX1 is upregulated in ESCC and promotes tumor cell proliferation and metastasis.
  • YBX1 stabilizes spermine oxidase (SMOX) mRNA via an m5C-dependent mechanism.
  • YBX1 activates the mTORC1 signaling pathway by stabilizing SMOX mRNA.

    • Conclusions:

    • YBX1 promotes ESCC development by stabilizing SMOX mRNA in an m5C-dependent manner.
    • YBX1 represents a potential therapeutic target for esophageal squamous cell carcinoma.