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The causal relationship between physical activity, sedentary behavior and brain cortical structure: a Mendelian

Yulin Sun1, Di Ma1, Zhenping Jiang1

  • 1Department of Sports Science, Hanyang University ERICA, 55, Hanyangdaehak-Ro, Sangnok-Gu, Ansan 15588, Republic of Korea.

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Regular physical activity may positively impact brain cortical thickness. Conversely, sedentary behavior might be linked to reduced cortical surface area and thickness in specific brain regions. These findings highlight lifestyle

Keywords:
Mendelian randomizationbrain cortical structurecausal effectphysical activitysedentary behavior

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Area of Science:

  • Neuroscience
  • Genetics
  • Public Health

Background:

  • Physical activity and sedentary behavior are distinct lifestyle factors impacting brain health.
  • The precise relationship between these behaviors and brain cortical structure remains unclear.

Purpose of the Study:

  • To investigate the causal association between physical activity, sedentary behavior, and brain cortical structure.
  • To analyze the impact on cortical surface area and cortical thickness.

Main Methods:

  • Employed Mendelian randomization analysis to infer causality.
  • Utilized the inverse-variance weighted method as the primary analytical approach.
  • Conducted sensitivity analyses to ensure the robustness and accuracy of findings.

Main Results:

  • Physical activity showed a potential positive association with cortical thickness in the bankssts and fusiform cortex.
  • Sedentary behavior was nominally linked to reduced cortical surface area in the caudal middle frontal and pars opercularis regions.
  • Sedentary behavior also showed a nominal positive correlation with inferior parietal cortical surface area and a negative correlation with paracentral cortical thickness.

Conclusions:

  • Findings suggest a potential causal link between physical activity, sedentary behavior, and specific brain cortical structures.
  • These results contribute to understanding how lifestyle choices influence brain morphology and overall brain health.