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Updated: Jun 29, 2025
Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
Published on: January 3, 2025
Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma
Avinash Shekhar Jaiswal1, Rakesh Kumar1, Aanchal Kakkar2
1Department of Otorhinolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Objective:
To assess the microvascular density (MVD) in juvenile nasopharyngeal angiofibroma (JNA) with CD34 immunostaining and evaluate its relationship with clinico-demographic features.
Methods:
This prospective study included patients with JNA undergoing endoscopic excision. The histopathological specimen was stained using CD-34 antibodies to calculate MVD. MVD and clinico-demographic features were correlated.
Results:
The study included 12 patients with a median age of 15.5 years. The mean MVD was 39 vessels/high power field (range 5 to 151 vessels). MVD was significantly associated only with the volume of tumour (r = 0.65, p = 0.02). The recurrence occurred in one patient with an MVD of 107. The median follow-up was 38 months.
Conclusion:
MVD is significantly associated with tumour volume in JNA, which implies a robust role of angiogenesis in the pathology of the tumour. Also, higher MVD may be a risk factor for recurrence.
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