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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: May 11, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

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Published on: February 15, 2022

Sclerectomy Reverses Nanophthalmic Optic Neuropathy.

Ahmad M Mansour¹, Sami H Uwaydat², Rola Hamam¹

¹Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.

Case Reports in Ophthalmology

|April 3, 2024

Summary

Surgical sclerectomy effectively treated vision loss in nanophthalmos by decompressing choroidal pressure. This procedure restored visual acuity and improved optic nerve appearance in a patient with this rare condition.

Keywords:

Choroidal thickness Nanophthalmos Optic neuropathy Peripapillary pachychoroid syndrome Sclerectomy

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Last Updated: May 11, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

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Transconjunctival Approach for Injection into the Rat Optic Nerve

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Published on: April 4, 2025

Area of Science:

Ophthalmology
Surgical Innovation

Background:

Nanophthalmos, a rare condition, presents challenges in diagnosing and treating unilateral disc swelling due to short axial length and thickened sclera.
Optic nerve head edema in nanophthalmos can lead to significant vision loss and requires innovative therapeutic approaches.

Observation:

A 59-year-old male experienced sudden vision reduction in one eye, diagnosed as nanophthalmos with optic disc swelling.
Optical coherence tomography revealed a crowded optic nerve head and significant choroidal thickening.
Standard neuro-ophthalmology workups were inconclusive, and no treatment was initially suggested.

Findings:

A novel surgical approach involving circumferential and radial posterior sclerotomy was performed to decompress choroidal pressure.
Post-operatively, the patient experienced rapid vision recovery and sustained improvement over six months.
Optical coherence tomography confirmed normalization of the optic nerve head contour and nerve fiber layer thickness.

Implications:

Sclerectomy demonstrates efficacy in treating compressive optic neuropathy associated with nanophthalmos.
This surgical technique may offer a potential treatment for other optic neuropathies linked to peripapillary pachychoroid conditions.
Further research into sclerectomy's role in managing various optic neuropathies is warranted.