Serdexmethylphenidate/dexmethylphenidate for children with attention-deficit/hyperactivity disorder: dose
Andrew J Cutler1,2, Scott H Kollins3,4, Matthew N Brams5
1State University of New York (SUNY) Upstate Medical University, Syracuse, NY, United States.
Frontiers in Psychiatry
|April 3, 2024
Summary
Optimized doses of serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) significantly improved ADHD symptoms in children. High responder rates were observed, indicating effective treatment for attention-deficit/hyperactivity disorder.
Area of Science:
- Pharmacology
- Pediatric Psychiatry
- Clinical Trials
Background:
- Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children.
- Effective pharmacotherapy is crucial for managing ADHD symptoms and improving quality of life.
- Optimizing stimulant dosage is essential for maximizing therapeutic benefits while minimizing side effects.
Purpose of the Study:
- To evaluate the treatment responder rate based on optimized serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) dosage.
- To assess changes in ADHD severity using the Attention-Deficit/Hyperactivity Disorder Rating Scale-5 (ADHD-RS-5) and Conners 3rd Edition-Parent scores.
- To determine the efficacy of SDX/d-MPH in children aged 6-12 years with ADHD.
Main Methods:
- A 21-day dose-optimization phase was conducted with 155 pediatric patients.
- Patients were titrated to optimal doses of SDX/d-MPH (26.1/5.2 mg, 39.2/7.8 mg, or 52.3/10.4 mg).
- Responder rates were defined as 30% and 50% reduction in ADHD-RS-5 scores; ADHD severity was assessed using Conners 3rd Edition-Parent scores.
Main Results:
- High responder rates (≥50%) were achieved across optimized dose groups, with up to 81.2% response at 39.2/7.8 mg by day 21.
- Significant improvements in ADHD severity were observed from baseline across all subscales of the Conners 3rd Edition-Parent scores.
- Optimized SDX/d-MPH dosages demonstrated clinical efficacy in reducing ADHD symptoms.
Conclusions:
- Optimized dosing of SDX/d-MPH leads to high treatment response rates in children with ADHD.
- SDX/d-MPH effectively reduces ADHD symptom severity.
- Further research into optimal SDX/d-MPH dosage regimens can enhance ADHD treatment strategies for pediatric populations.
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