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  11. The Prognostic Value And Potential Immune Mechanisms Of Lncrnas Related To Immunogenic Cell Death In Papillary Thyroid Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Prognostic Value And Potential Immune Mechanisms Of Lncrnas Related To Immunogenic Cell Death In Papillary Thyroid Carcinoma.

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The Prognostic Value and Potential Immune Mechanisms of lncRNAs Related to Immunogenic Cell Death in Papillary Thyroid Carcinoma.

Yixian Wang1, Xin Li2, Yinde Huang3

  • 1Department of Vascular and Thyroid Surgery, The First Hospital, China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.

Journal of Inflammation Research
|April 3, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Immunogenic cell death-related long non-coding RNAs (lncRNAs) serve as prognostic biomarkers for papillary thyroid carcinoma (PTC). LINC00924 demonstrates a protective role, inhibiting PTC progression by reducing cell proliferation and invasion.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) linked to immunogenic cell death (ICD) are crucial in tumorigenesis and prognosis for papillary thyroid carcinoma (PTC).
  • Understanding the role of ICD-related lncRNAs is vital for developing new therapeutic strategies and prognostic tools for PTC patients.

Purpose of the Study:

  • To investigate the impact of ICD-related lncRNAs on the prognosis of papillary thyroid carcinoma (PTC).
  • To develop a prognostic model based on ICD-related lncRNAs and explore the function of LINC00924 in PTC.

Main Methods:

  • Utilized The Cancer Genome Atlas-Thyroid carcinoma database (TCGA-THCA) for sample analysis and consensus cluster analysis.
  • Developed a prognostic model, performed GO and KEGG enrichment analyses, and assessed immune cell infiltration (ICI), immune checkpoints, tumor mutation burden (TMB), tumor microenvironment (TME), TIDE, TCIA, and drug sensitivity.
Keywords:
LncRNAimmunogenic cell deathpapillary thyroid carcinomaprognosis

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  • Conducted in vitro experiments (EdU, wound scratch, Transwell, flow cytometry) to evaluate LINC00924's role in PTC cell lines.

    • Main Results:

    • Identified two distinct clusters with varying TME, BRAF, NRAS, and ICI characteristics, indicating potential immune mechanisms in PTC.
    • A prognostic model identified seven key lncRNAs (SRRM2-AS1, AC008556.1, BHLHE40-AS1, EGOT, AL39066.1, LINC00924, PICART1) whose expression correlated with progression-free interval (PFI).
    • Overexpression of LINC00924 significantly inhibited PTC cell proliferation, migration, and invasion, while promoting apoptosis.

    Conclusions:

    • ICD-related lncRNAs show promise as prognostic biomarkers for progression-free interval (PFI) in PTC patients.
    • In vitro findings suggest LINC00924 plays a protective role in papillary thyroid carcinoma progression.