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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
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Exploring the Correlation Between Splenomegaly and Lung Involvement in COVID-19: A Retrospective Study
Bharathi Priya Raju1, Balaji Selvaraj2, Sharmila Murugesan3
1Radiodiagnosis, Government Stanley Medical College and Hospital, Chennai, IND.
Cureus
|April 3, 2024
Summary
This study found a weak, non-significant link between spleen enlargement and lung involvement in COVID-19 patients. Spleen size is not a reliable predictor of pulmonary complications in coronavirus disease 2019.
Area of Science:
- Infectious Diseases
- Radiology
- Pulmonology
Background:
- Coronavirus disease 2019 (COVID-19) impacts multiple organ systems beyond the respiratory tract.
- Splenomegaly (enlarged spleen) is a noted extrapulmonary manifestation of COVID-19.
- The relationship between splenomegaly and lung involvement in COVID-19 remains unclear.
Purpose of the Study:
- To investigate the correlation between spleen size, assessed via CT imaging, and the extent of lung involvement in COVID-19 patients.
- To explore potential prognostic value of splenomegaly in COVID-19 severity.
Main Methods:
- Retrospective cross-sectional study of 1058 symptomatic COVID-19 patients.
- Computed tomography (CT) imaging used to measure spleen size and lung involvement (LI).
- Statistical analysis including Pearson correlation and linear regression.
Main Results:
- Mean spleen size was 9.49 cm; mean LI score was 0.272.
- A marginal positive correlation (r=0.0495) was observed between spleen size and LI.
- Spleen size explained only 0.2% of the variance in LI scores, indicating minimal impact.
Conclusions:
- A statistically non-significant correlation exists between splenomegaly and lung involvement in COVID-19.
- Splenic enlargement may indicate systemic disease but is not a strong independent predictor of lung damage.
- Further research is needed to understand the full implications of splenic involvement in COVID-19.
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