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Metabolic dysfunction-associated fatty liver disease: current therapeutic strategies
Khamis Al Hashmi1, Rosaria Vincenza Giglio2,3, Anca Pantea Stoian4
1Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Frontiers in Nutrition
|April 3, 2024
Summary
Metabolic Associated Fatty Liver Disease (MAFLD) now includes cardiometabolic risk factors. This review explores lifestyle changes and therapies, including nutraceuticals and pharmaceuticals, for managing MAFLD and its related conditions.
Area of Science:
- Hepatology
- Cardiology
- Endocrinology
Background:
- Metabolic Associated Fatty Liver Disease (MAFLD) definition incorporates cardiometabolic criteria, replacing Nonalcoholic Fatty Liver Disease (NAFLD).
- MAFLD emphasizes the bidirectional relationship between hepatic steatosis, Type 2 Diabetes Mellitus (T2DM), and Cardiovascular Disease (CVD).
Purpose of the Study:
- To review current therapeutic strategies for MAFLD treatment and prevention.
- To explore the role of lifestyle modifications, nutraceuticals, and pharmacological agents in managing MAFLD.
Main Methods:
- Literature review of studies on MAFLD, T2DM, CVD, and related therapies.
- Analysis of evidence supporting nutraceuticals (e.g., silymarin, berberine, vitamin E) and pharmaceuticals (e.g., incretins, PCSK9 inhibitors).
Main Results:
- Lifestyle modification (nutrition, physical activity) is the cornerstone of MAFLD therapy.
- Several nutraceuticals show potential benefits for metabolic alterations and hepatic steatosis, but long-term data is needed.
- Pharmacological therapies like incretins and PCSK9 inhibitors offer breakthroughs in preventing and reducing cardiometabolic risk in MAFLD patients.
Conclusions:
- MAFLD management requires a comprehensive approach addressing hepatic, metabolic, and cardiovascular aspects.
- Further research is needed to establish long-term efficacy and safety of various MAFLD therapies.
- Integrated therapeutic strategies are crucial for effective MAFLD treatment and prevention of complications.
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