Postmenopausal women with higher TSH values within the normal range present improved handgrip strength: a pilot study

Area of Science:

• Endocrinology
• Gerontology
• Musculoskeletal Health

Background:

• Thyroid function plays a role in metabolic processes and body composition.
• Subclinical thyroid dysfunction can impact bone and muscle health.
• Postmenopausal women are at increased risk for musculoskeletal decline.

Purpose of the Study:

• To investigate the association between thyroid function within the euthyroid range and musculoskeletal parameters, including bone mineral density and muscle strength.
• To explore the relationship between thyroid function and body composition in postmenopausal women.

Main Methods:

• A cross-sectional study of 96 postmenopausal women with normal serum thyroid-stimulating hormone (TSH) levels.
• Measurements included Dual Energy X-ray absorptiometry (DXA) for bone status and body composition, and handgrip strength (HGS) for muscle strength.
• Biochemical assessments and physical activity questionnaires were also utilized.

Main Results:

• Serum TSH showed a positive correlation with handgrip strength (HGS) and total body bone mineral density (BMD) T-scores.
• Lower muscle strength (HGS < 16 kg) was associated with significantly lower TSH levels within the normal range.
• HGS was independently associated with TSH measurements and BMD T-scores in multivariable regression analysis.

Conclusions:

• Lower serum TSH values within the normal range are associated with reduced muscle strength in postmenopausal women.
• These findings suggest a potential link between subtle thyroid function variations and musculoskeletal health.
• Further research is warranted to confirm these preliminary observations and understand their clinical implications.