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Updated: Jun 29, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Triethyl amine as an effective reducing agent for sulfoxide deoxygenation

Xiaojing Gao1, Fumin Chen1, Ming Yu Jin1

  • 1Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China. xuc@sustech.edu.cn.

Organic & Biomolecular Chemistry
|April 3, 2024
PubMed
Summary

A new chemical method efficiently converts sulfoxides to sulfides using triethyl amine and thionyl chloride. Triethyl amine acts as an electron donor, enabling a broad range of sulfoxide substrates for this deoxygenation reaction.

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