Related Experiment Video
Updated: Jun 29, 2025
09:03
Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
Published on: November 7, 2020
4.8K
Chapare virus infection and current perspectives on dentistry
Marco Guevara-Vega1,2, Bruno Silva Andrade3, Lucas Sousa Palmeira4
1Innovation Center in Salivary Diagnostics and Nanobiotechnology, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.
Clinical Oral Investigations
|April 3, 2024
Summary
Chapare virus (CHAV) can spread between people through saliva and aerosols, posing risks in dental settings. Preventive strategies and salivary diagnostics are crucial for dentists and healthcare workers to combat CHAV transmission.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Background:
- Chapare virus (CHAV) poses a significant risk in dental settings due to potential oral transmission.
- Gingival hemorrhage is a common symptom in CHAV-infected patients, increasing transmission concerns.
- Human-to-human transmission of CHAV is increasingly recognized, including through saliva, blood, urine, droplets, and aerosols.
Purpose of the Study:
- To review Chapare virus entry into oral cells, transmission routes, and preventive measures for dental professionals.
- To highlight the importance of infection control in dental settings for CHAV prevention.
- To explore the role of salivary diagnostics in managing CHAV outbreaks.
Main Methods:
- Comprehensive literature search of CHAV-related studies across major scientific databases (MEDLINE/PubMed, Scopus, EMBASE, Web-of-Science).
- In silico bioinformatics and molecular dynamic analysis to identify critical residues in the CHAV pre-glycoprotein (GP) complex interacting with human transferrin receptor 1 (TfR1).
- Review of existing evidence on CHAV detection in saliva and gingival bleeding in infected patients.
Main Results:
- CHAV transmission occurs via direct contact with bodily fluids (saliva, blood, urine) and through aerosols generated during healthcare procedures.
- CHAV has been detected in human saliva, and gingival bleeding is a consistent finding in hemorrhagic fever cases.
- Nosocomial transmission to healthcare workers has been documented, emphasizing workplace risks.
- Identification of specific interactions between CHAV GP complex and human TfR1 in oral tissues.
Conclusions:
- Dentists and healthcare workers require specific preventive strategies against CHAV, particularly concerning aerosol-generating procedures.
- Salivary diagnostic platforms are essential for rapid virus detection and implementing urgent plans to prevent human-to-human CHAV transmission.
- Multidisciplinary approaches are vital for effective CHAV control in clinical settings.
Related Concept Videos
01:20Infection
7.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.9K
01:22Healthcare Associated Infections II: Preventive Measures
2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
01:21Tooth Anatomy
461
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
461
00:50What are Viruses?
114.9K
Overview
114.9K
01:17Transmission-based Precautions I: Contact, Enteric, and Droplets
3.6K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
3.6K
01:15Teeth
406
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
406