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Asprosin: its function as a novel endocrine factor in metabolic-related diseases
1Department of Endocrinology, Shandong Rongjun General Hospital, 23 Jiefang Road, Jinan, 250013, Shandong Province, China.
Journal of Endocrinological Investigation
|April 3, 2024
Summary
Asprosin, a hormone from fibrillin-1, impacts metabolic diseases like obesity and diabetes. This review details its tissue-specific functions and therapeutic potential for metabolic disorders.
Area of Science:
- Endocrinology
- Metabolic Research
Background:
- Asprosin is a newly identified endocrine hormone derived from fibrillin-1 cleavage.
- It is implicated in the pathogenesis of metabolic diseases including obesity, NAFLD, diabetes, PCOS, and cardiovascular conditions.
Purpose of the Study:
- To review recent advancements in understanding asprosin.
- To explore the multifaceted roles of asprosin in various physiological and pathological processes.
Main Methods:
- This study employed a narrative review methodology.
- Literature search and synthesis of existing research on asprosin.
Main Results:
- Asprosin exhibits tissue-specific functions across multiple organs.
- Key tissues examined include white adipose tissue, liver, hypothalamus, gonads (testis, ovary), heart, pancreas, skeletal muscle, and kidney.
Conclusions:
- Asprosin is a versatile protein with significant roles in diverse physiological and pathological contexts.
- Further investigation is warranted to elucidate asprosin's mechanisms and therapeutic potential for metabolic diseases.
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