Power-integrated, wireless neural recording systems on the cranium using a direct printing method for deep-brain...

Area of Science:

• Neuroscience and Bioengineering
• Materials Science and Engineering
• Implantable Electronic Devices

Background:

• Conventional neural recording devices utilize bulky, rigid batteries, limiting natural subject behavior and posing safety risks.
• Existing power sources in head-mounted neural systems restrict precise behavioral interpretation and can cause overheating or leakage.

Purpose of the Study:

• To develop a novel, power-integrated wireless neural recording system that seamlessly conforms to the cranium.
• To overcome the limitations of conventional batteries in neural interfaces for enhanced biocompatibility and data acquisition.

Main Methods:

• Direct 3D printing of a quasi-solid-state Zinc-ion microbattery geometrically synchronized to a mouse skull.
• Integration of soft deep-brain neural probes, interconnections, and auxiliary electronics using printable liquid metals.
• In vivo biocompatibility and reliability testing in mouse models.

Main Results:

• Successful demonstration of a fully printed, cranial-conforming wireless neural recording system.
• Reliable monitoring of neural activities across extensive brain regions in mice without significant heat generation.
• High resolution and biocompatibility confirmed through in vivo studies.

Conclusions:

• The all-printed neural interface system offers a bio-conformable and customizable solution for brain research.
• This technology revolutionizes neural recording by enabling naturalistic experimentation and improving data quality.
• The printed system addresses safety concerns associated with traditional batteries in neural implants.