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[Second-trimester abortions induced by dinoprost].

J P Feldman, J Jahier, A Mavel

    Revue Francaise De Gynecologie Et D'Obstetrique
    |February 1, 1985
    PubMed
    Summary
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    Prostaglandin F2 alpha effectively induces second trimester abortions with minimal trauma. Intracervical gel instillation is preferred, with intra-amniotic injection as a highly effective alternative for uterine evacuation.

    Area of Science:

    • Obstetrics and Gynecology
    • Reproductive Medicine
    • Pharmacology

    Context:

    • Second-trimester abortions often require effective and safe induction methods.
    • Surgical evacuation carries risks, necessitating alternatives for uterine evacuation.
    • Prostaglandins are recognized for their role in gynecological procedures.

    Purpose:

    • To evaluate the efficacy and safety of prostaglandin F2 alpha for inducing second-trimester abortions.
    • To compare two methods of prostaglandin F2 alpha administration: intracervical gel and intra-amniotic injection.
    • To determine the least traumatic and most effective approach for non-surgical uterine evacuation.

    Summary:

    • Intracervical instillation of prostaglandin F2 alpha in Tylose gel proved to be a minimally traumatic method for uterine evacuation in most cases (18/24).

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  • This method offers ease of administration, repeatability, and a favorable safety profile with no serious complications reported.
  • For treatment failures, intra-amniotic prostaglandin F2 alpha injection (40 mg) demonstrated high effectiveness (31/33), though requiring experienced personnel and ultrasonography.

    • Impact:

    • Provides evidence for safe and effective non-surgical induction of second-trimester abortions, reducing the need for surgical interventions.
    • Highlights prostaglandin F2 alpha as a viable option for uterine evacuation, with specific administration techniques outlined for different scenarios.
    • Offers clinicians a choice between a less invasive, repeatable method and a highly effective injection-based approach for managing second-trimester pregnancy terminations.