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Assessing the impact of tear direction in coronary artery dissection on thrombosis development: A hemodynamic
Yan Pei1, Pan Song2, Kaiyue Zhang1
1Department of Computer Science and Technology, Southwest University of Science and Technology, No. 59, middle of Qinglong Avenue, Fucheng District, Mianyang, 621010, China.
Insights
The direction of coronary artery dissection (CAD) tears impacts outcomes. Transverse tears pose a higher risk of early thrombosis and ischemia, while longitudinal tears may cause increased vessel wall injury due to altered blood flow dynamics.
Area of Science:
- Cardiovascular research
- Biomedical engineering
- Medical imaging
Background:
- Iatrogenic coronary artery dissection (CAD) is a complication of catheter manipulation.
- The influence of tear direction on CAD prognosis is not well understood.
Purpose of the Study:
- To investigate the hemodynamic effects of transverse versus longitudinal CAD tears.
- To evaluate the risk of thrombosis, rupture, and further dilatation in different CAD tear types.
Main Methods:
- Reconstructed 3D CAD models (transverse and longitudinal tears) from CTA data.
- Analyzed wall shear stress (WSS) indicators: TAWSS, OSI, RRT, CFI.
- Utilized a thrombus growth model to predict thrombus progression.
Main Results:
- No significant differences in TAWSS, RRT, or CFI between tear types.
- Significant difference observed in oscillatory shear index (OSI) (p < 0.05).
- Transverse tears showed earlier thrombus extension into the true lumen.
Conclusions:
- Transverse tears risk further dissection propagation.
- Longitudinal tears create low TAWSS and high OSI, increasing vessel wall injury risk.
- Transverse tears may lead to higher early thrombosis, obstruction, and ischemia risk.
Objective:
Iatrogenic coronary artery dissection is a complication of coronary intimal injury and dissection due to improper catheter manipulation. The impact of tear direction on the prognosis of coronary artery dissection (CAD) remains unclear. This study examines the hemodynamic effects of different tear directions (transverse and longitudinal) of CAD and evaluates the risk of thrombosis, rupture and further dilatation of CAD.
Methods:
Two types of CAD models (Type I: transverse tear, Type II: longitudinal tear) were reconstructed from the aorto-coronary CTA dataset of 8 healthy cases. Four WSS-based indicators were analyzed, including time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), and cross flow index (CFI). A thrombus growth model was also introduced to predict the trend of thrombus growth in CAD with two different tear directions.
Results:
For most of the WSS-based indicators, including TAWSS, RRT, and CFI, no statistically significant differences were observed across the CAD models with varying tear directions, except for OSI, where a significant difference was noted (p < 0.05). Meanwhile, in terms of thrombus growth, the thrombus growing at the tear of the Type I (transverse tear) CAD model extended into the true lumen earlier than that of the Type II (longitudinal tear) model.
Conclusions:
Numerical simulations suggest that: (1) The CAD with transverse tear have a high risk of further tearing of the dissection at the distal end of the tear. (2) The CAD with longitudinal tear create a hemodynamic environment characterized by low TAWSS and high OSI in the false lumen, which may additionally increase the risk of vessel wall injury. (3) The CAD with transverse tear may have a higher risk of thrombosis and coronary obstruction and myocardial ischemia in the early phase of the dissection.
