Potential therapeutic applications of circular RNA in acute kidney injury
1Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Abstract:
Acute kidney injury (AKI) is a common clinical syndrome characterized by a rapid deterioration in renal function, manifested by a significant increase in creatinine and a sharp decrease in urine output. The incidence of morbidity and mortality associated with AKI is on the rise, with most patients progressing to chronic kidney disease or end-stage renal disease. Treatment options for patients with AKI remain limited. Circular RNA (circRNA) is a wide and diverse class of non-coding RNAs that are present in a variety of organisms and are involved in gene expression regulation. Studies have shown that circRNA acts as a competing RNA, is involved in disease occurrence and development, and has potential as a disease diagnostic and prognostic marker. CircRNA is involved in the regulation of important biological processes, including apoptosis, oxidative stress, and inflammation. This study reviews the current status and progress of circRNA research in the context of AKI.
Insights
Circular RNAs (circRNAs) are key regulators in gene expression and are implicated in acute kidney injury (AKI) development. This review explores circRNA
Area of Science:
- Biochemistry
- Molecular Biology
- Nephrology
Background:
- Acute kidney injury (AKI) is a prevalent clinical syndrome with increasing morbidity and mortality.
- Current treatment options for AKI are limited, and many patients progress to chronic kidney disease.
- Circular RNAs (circRNAs) are non-coding RNAs involved in gene regulation and disease development.
Purpose of the Study:
- To review the current research status and progress of circRNAs in the context of AKI.
- To highlight the role of circRNAs in biological processes relevant to AKI, such as apoptosis, oxidative stress, and inflammation.
- To discuss the potential of circRNAs as diagnostic and prognostic markers for AKI.
Main Methods:
- Literature review of studies on circRNAs and AKI.
- Analysis of circRNA involvement in gene expression regulation.
- Examination of circRNA's role in apoptosis, oxidative stress, and inflammation in AKI models.
Main Results:
- CircRNAs play a significant role in the occurrence and development of AKI.
- CircRNAs act as competing RNAs, influencing gene expression.
- CircRNAs are implicated in regulating key biological processes like apoptosis, oxidative stress, and inflammation in AKI.
Conclusions:
- CircRNAs are critically involved in the pathogenesis of AKI.
- CircRNAs hold promise as potential diagnostic and prognostic biomarkers for AKI.
- Further research into circRNAs could lead to novel therapeutic strategies for AKI.
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