Spatiotemporal distribution of mediastinal neoplasms: A comprehensive multi-center study

Yu Jiang ¹, Yuechun Lin ¹, Chao Yang ¹

¹Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
²Department of Pathology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
³Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
⁴Department of Thoracic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
⁵Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511495, China.
⁶Department of Thoracic Surgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou 730030, China.
⁷Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
⁸Department of Cardiothoracic Surgery, Zhongshan City People's Hospital, Zhongshan 528403, China.
⁹Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350000, China.
¹⁰Department of Thoracic Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
¹¹Division of Thoracic Surgery, Sichuan Cancer Hospital & Institute, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
¹²Department of Thoracic Surgery, the University of Hong Kong-Shenzhen Hospital, Shenzhen 518004, China.

⁰Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.

Lung +

|

April 3, 2024

View abstract on PubMed

Summary

Mediastinal neoplasms show varied distribution by age and location. Thymomas, cysts, and neurogenic tumors are common, with regional differences compared globally. Understanding this is key for diagnosis and treatment.

Area Of Science

Thoracic oncology
Medical imaging
Epidemiology

Background

Mediastinal neoplasms are uncommon but serious thoracic diseases.
Accurate diagnosis and treatment require understanding their spatiotemporal distribution.
Previous studies lack comprehensive data coverage.

Purpose Of The Study

To elucidate the spatiotemporal distribution of mediastinal lesions.
To provide insights into mediastinal neoplasm epidemiology.
To inform differential diagnosis and disease control strategies.

Main Methods

Multi-center, hospital-based observational study (20 institutions).
Retrospective analysis of electronic medical records (2009-2020).
Inclusion of sociodemographic data, CT images, and pathology; comparison with global data.

Main Results

Thymomas (30.7%), benign cysts (23.4%), and neurogenic tumors (10.0%) were most common.
Distribution varied by mediastinal compartment: thymomas (prevascular), cysts (visceral), neurogenic tumors (paravertebral).
Age-specific patterns observed; Chinese population data differs from global data.

Conclusions

Significant heterogeneity exists in mediastinal neoplasm spatiotemporal distribution.
Findings offer valuable demographic data for differential diagnosis.
Results aid in tailoring disease prevention and control strategies.

Keywords:

Epidemiology Mediastinal neoplasms Spatiotemporal distribution Thymomas