Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combining Inflammation and Tissue Turnover in the Modeling of Atherosclerosis Development Following the Outside-In Disease Approach.

International journal for numerical methods in biomedical engineering·2025
Same author

Implication of Some Modelling Assumptions on Biomechanical Factors of Abdominal Aortic Aneurysm.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2025
Same author

Micromechanical heterogeneity in abdominal aortic aneurysms is associated with rupture risk.

Acta biomaterialia·2025
Same author

Community challenge towards consensus on characterization of biological tissue: C<sup>4</sup>Bio's first findings.

Journal of biomechanics·2025
Same author

Data Driven Models Merging Geometric, Biomechanical, and Clinical Data to Assess the Rupture of Abdominal Aortic Aneurysms.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2025
Same author

Corrigendum to "Fracture of porcine aorta-Part 1: symconCT fracture testing and DIC" [Acta Biomaterialia 2023, 167, 147-157].

Acta biomaterialia·2025

Related Experiment Video

Updated: Jun 29, 2025

Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens
09:29

Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens

Published on: January 24, 2016

9.4K

Specimen width affects vascular tissue integrity for in-vitro characterisation.

Marta Alloisio1, Joey J M Wolffs2, T Christian Gasser1

  • 1Material and Structural Mechanics, Department of Engineering Mechanics, KTH Royal Institute of Technology, Sweden.

Journal of the Mechanical Behavior of Biomedical Materials
|April 3, 2024
PubMed
Summary
This summary is machine-generated.

Preparing slender tissue specimens can alter mechanical properties. Narrower axial specimens (4 mm) showed reduced vascular wall stiffness (~40%), indicating cutting trauma affects results.

Keywords:
Fiber slidingFinite element modelMechanical traumaSize effectTensile testing

More Related Videos

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

12.2K
An in vivo Assay to Test Blood Vessel Permeability
07:03

An in vivo Assay to Test Blood Vessel Permeability

Published on: March 16, 2013

64.7K

Related Experiment Videos

Last Updated: Jun 29, 2025

Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens
09:29

Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens

Published on: January 24, 2016

9.4K
A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

12.2K
An in vivo Assay to Test Blood Vessel Permeability
07:03

An in vivo Assay to Test Blood Vessel Permeability

Published on: March 16, 2013

64.7K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cardiovascular Research

Background:

  • In vitro characterization of tissue mechanical properties is crucial for understanding disease and developing treatments.
  • Specimen preparation methods can inadvertently alter native tissue biomechanics.
  • Porcine aorta serves as a relevant model for human arterial tissue studies.

Purpose of the Study:

  • To investigate the impact of specimen preparation, specifically strip width, on the mechanical properties of porcine aortic tissue.
  • To determine if cutting during specimen preparation introduces artifacts affecting uniaxial tensile test results.
  • To differentiate effects on circumferentially versus axially loaded specimens.

Main Methods:

  • Rectangular specimens of porcine aortic wall were prepared with varying widths (16 mm, 8 mm, 4 mm) using cuts parallel to the loading direction.
  • Uniaxial tensile loading was applied along the circumferential and axial directions of the aorta.
  • Finite element analysis (FEA) was used to model fiber sliding and specimen behavior.

Main Results:

  • Circumferentially loaded specimens exhibited consistent mechanical properties regardless of width.
  • Axially loaded specimens showed reduced vascular wall stiffness by approximately 40% in the narrowest (4 mm) strips.
  • Specimen width significantly influenced cross-loading stretch, with fiber sliding contributing to softening in slender specimens.

Conclusions:

  • Cutting specimens orthogonal to collagen fiber direction induces mechanical trauma, weakening slender tensile specimens.
  • The preparation of narrow, axially loaded aortic specimens compromises the accurate determination of native mechanical properties.
  • Careful consideration of specimen geometry and preparation is essential for reliable in vitro biomechanical testing of vascular tissues.