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Related Concept Videos

Metal-Ligand Bonds02:51

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
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Polydopamine-Mediated Metal-Organic Frameworks Modification for Improved Biocompatibility.

Jiayu Feng1, Liwang Xu1, Lulu Qi1

  • 1College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China.

Macromolecular Bioscience
|April 3, 2024
PubMed
Summary
This summary is machine-generated.

Polydopamine coating significantly reduces the toxicity of zeolitic imidazolate framework-8 (ZIF-8) nanomaterials in cells. This biocompatible modification enhances the potential of metal-organic frameworks (MOFs) for safe nanomedicine and drug delivery applications.

Keywords:
biocompatibilityhuman umbilical vein endothelial cellspolydopaminezebrafishzeolitic imidazolate framework‐8

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Area of Science:

  • Biomaterials Science
  • Nanomedicine
  • Cellular Toxicology

Background:

  • Engineered nanomaterials offer significant biomedical potential but face challenges due to insufficient biocompatibility data.
  • Metal-organic frameworks (MOFs), specifically zeolitic imidazolate framework-8 (ZIF-8), are emerging as key players in nanomedicine.
  • Understanding and mitigating the cellular toxicity of nanomaterials is crucial for their clinical translation.

Purpose of the Study:

  • To investigate the effect of polydopamine (PDA) coating on the biocompatibility of ZIF-8 nanomaterials.
  • To elucidate the mechanisms underlying ZIF-8 induced cytotoxicity.
  • To evaluate the potential of PDA-modified ZIF-8 for safe nano-based drug delivery systems.

Main Methods:

  • In vitro cytotoxicity assays using RAW264.7, LO2, and HST6 cell lines.
  • Assessment of reactive oxygen species (ROS) generation, cell cycle, and autophagy.
  • In vivo assays using human umbilical vein endothelial cells and zebrafish embryos.

Main Results:

  • PDA coating significantly alleviated the cytotoxicity of ZIF-8 across multiple cell types.
  • ZIF-8 induced cytotoxicity by increasing ROS generation, leading to cell cycle delay and autophagy.
  • PDA modification effectively mitigated ZIF-8 toxicity in both in vitro and in vivo models.

Conclusions:

  • Polydopamine coating is a viable strategy to enhance the biocompatibility of ZIF-8 nanomaterials.
  • PDA-coated MOFs demonstrate reduced cellular toxicity, paving the way for safer nanomedicine applications.
  • This study highlights the potential of PDA-modified MOFs in developing advanced drug delivery systems.