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Brain Metastasis of Non-small Cell Lung Cancer After Disease-Free Survival of 5 years: Case Series and Comprehensive
Takahiro Suzuki1, Shoichi Deguchi2, Keigo Matsushima3
1Division of Neurosurgery, Shizuoka Cancer Center, Shizuoka, Japan; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
World Neurosurgery
|April 3, 2024
Summary
Late recurrent brain metastasis (LRBM) is rare in nonsmall cell lung cancer (NSCLC) patients. This study found LRBM patients often have driver gene mutations and can achieve long-term survival with aggressive treatment.
Area of Science:
- Oncology
- Neurology
- Genetics
Background:
- Nonsmall cell lung cancer (NSCLC) cure is defined by 5-year disease-free survival.
- Brain metastases occurring after 5 years of disease-free survival are termed late recurrent brain metastasis (LRBM).
Purpose of the Study:
- To evaluate the characteristics and outcomes of NSCLC patients who develop LRBM.
- To understand the clinical presentation and prognosis of LRBM in NSCLC.
Main Methods:
- Retrospective review of 1281 patients with lung cancer brain metastases.
- Inclusion of 6 patients with LRBM and a systematic literature review of 6 relevant studies.
Main Results:
- LRBM occurred in 0.47% of patients, with a median latency of 13 years post-treatment.
- All LRBM patients had adenocarcinoma, 5/6 had driver gene mutations, and underwent craniotomy.
- No local intracranial recurrence was observed; 5 patients achieved long-term survival post-craniotomy.
Conclusions:
- Late recurrent brain metastasis (LRBM) is a rare event in nonsmall cell lung cancer (NSCLC).
- Patients with LRBM frequently harbor driver gene mutations and can achieve long-term survival with aggressive local therapy.
- Multicenter studies are needed to further investigate LRBM in NSCLC.
