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Updated: Jun 29, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Advances on Senescence-associated secretory phenotype regulated by circular RNAs in tumors

Yue Qiu1, Shiqi Zhang2, Changfeng Man1

  • 1Cancer Institute, Affiliated People's Hospital of Jiangsu University, No 8, Dianli Road, Zhenjiang, Jiangsu 212002, People's Republic of China.

Ageing Research Reviews
|April 3, 2024
PubMed

Insights

Circular RNAs (circRNAs) regulate the senescence-associated secretory phenotype (SASP) in tumors. This review explores circRNA-SASP interactions for cancer diagnosis and therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Aging

Background:

  • The senescence-associated secretory phenotype (SASP) comprises factors like cytokines and lipids, influencing tissue homeostasis and cancer progression.
  • Circular RNAs (circRNAs) are non-coding RNAs involved in gene regulation, with aberrant expression linked to various pathologies, including cancer.

Purpose of the Study:

  • To review the bidirectional modulation between SASP and circRNAs in tumors.
  • To explore the role of circRNAs in regulating SASP factors across different cancer types.
  • To offer new insights for cancer diagnosis and therapeutic strategies.

Main Methods:

  • Literature review focusing on studies investigating circRNAs and SASP in oncological contexts.
  • Analysis of existing research on circRNA-SASP interactions and their impact on tumor development.
  • Synthesis of findings to highlight current knowledge gaps and future directions.

Main Results:

  • circRNAs modulate SASP factors, influencing both cancer suppression and progression.
  • Aberrant expression of circRNAs is observed in pathological conditions, including cancer.
  • The interplay between circRNAs and SASP in tumors is a developing area of research.

Conclusions:

  • circRNAs play a significant role in regulating SASP, impacting tumor biology.
  • Understanding circRNA-SASP interactions offers potential for novel cancer biomarkers and therapeutic targets.
  • Further research is crucial to fully elucidate these mechanisms for clinical application.
Keywords:
Cellular senescenceCircular RNASenescence-associated secretory phenotypeTumor

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