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Updated: Jun 29, 2025
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
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Association Between RORA Polymorphisms and Obesity.
Shahryar Azizi1, Parisa Esmaeili Motlagh2, Solat Eslami3,4
1Department of Surgery, Erfan Niayesh Hospital, Tehran, Iran.
Biochemical Genetics
|April 3, 2024
Summary
Genetic variations in the RORA gene, specifically rs11639084 and rs4774388, are strongly associated with severe obesity in the Iranian population, highlighting RORα
Area of Science:
- Genetics
- Metabolic Disorders
- Molecular Biology
Background:
- RORα (Retinoid-related Orphan Receptor Alpha) is a nuclear receptor transcription factor.
- RORα plays a role in regulating metabolic processes and has been implicated in conditions such as obesity.
Purpose of the Study:
- To investigate the association between two specific single nucleotide polymorphisms (SNPs) in the RORA gene (rs11639084 and rs4774388) and severe obesity.
- To identify potential genetic risk factors for obesity within the Iranian population.
Main Methods:
- Case-control study design.
- Genotyping of RORA gene polymorphisms rs11639084 and rs4774388 in an Iranian cohort.
- Statistical analysis including allelic, co-dominant, and recessive genetic models to assess SNP-obesity associations.
Main Results:
- Both rs11639084 and rs4774388 SNPs showed a significant association with severe obesity (P < 0.0001).
- The T allele of rs11639084 (OR = 16.85) and the C allele of rs4774388 (OR = 4.61) were identified as risk alleles.
- Specific genotypes (TT for rs11639084 and CC for rs4774388) demonstrated strong associations with obesity under different genetic models.
Conclusions:
- The RORA gene, through polymorphisms rs11639084 and rs4774388, contributes to the pathogenesis of severe obesity in the Iranian population.
- These findings suggest RORα as a potential therapeutic target for obesity management.
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