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Related Experiment Video

Updated: Jul 6, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

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Visualizing features with wide-field volumetric OCT angiography.

Tristan T Hormel, Guangru B Liang, Xiang Wei

|April 4, 2024

Summary

A new swept-source Optical Coherence Tomography (OCT) system captures a 12x23mm field of view, revealing pathologies and novel features in a single scan. This advanced imaging technology enhances visualization for blinding diseases like AMD and DR.

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT

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Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Optical coherence tomography (OCT) and OCT angiography (OCTA) are crucial non-invasive imaging tools for high-resolution, depth-resolved tissue and angiographic information.
Current OCT devices are limited by a restricted field of view, hindering the comprehensive assessment of pathologies in blinding diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR).

Purpose of the Study:

To introduce a novel swept-source OCT system capable of acquiring an expanded field of view in a single acquisition.
To demonstrate the system's ability to identify conventional and novel pathological features relevant to blinding eye diseases.

Main Methods:

Development and implementation of a swept-source OCT device designed for ultra-wide field imaging.
Acquisition of single-shot, high-resolution images covering up to a 12x23 mm field of view.
Analysis of captured images to identify known pathologies and previously unresolvable structures.

Main Results:

The swept-source OCT system successfully captured an unprecedented 12x23 mm field of view in a single shot.
Conventional pathologies, including non-perfusion areas, were identified beyond the limits of standard OCT imaging.
Novel features such as choriocapillaris morphology and inner limiting membrane macrophage-like cells were visualized, indicating potential disease implications.

Conclusions:

The developed ultra-wide field swept-source OCT technology significantly expands imaging capabilities beyond conventional limitations.
This advancement allows for the detection of both established and new pathological indicators, offering improved diagnostic potential for blinding retinal diseases.