Advancing Cancer Interception
Susan M Domchek1,2,3, Robert H Vonderheide2,3
1Basser Center for BRCA1/2, University of Pennsylvania, Philadelphia, Pen-nsylvania.
Cancer Discovery
|April 4, 2024
Abstract:
Rapid advances in technology and therapeutics, along with better methods to discern who is at risk for cancer by genetic testing and other means, has enabled the development of cancer interception. Targeted therapies and "immuno-interception" may eliminate premalignant lesions and require clinical trial and treatment paradigms altogether distinct from current approaches.
Insights
Cancer interception, using advanced technology and genetic testing, aims to eliminate pre-cancerous conditions. New targeted therapies and immuno-interception strategies require distinct clinical approaches distinct from current cancer treatments.
Area of Science:
- Oncology
- Genetics
- Therapeutics
Background:
- Technological and therapeutic advancements are accelerating cancer research.
- Improved methods for identifying individuals at risk for cancer are emerging.
- Genetic testing offers new avenues for personalized cancer risk assessment.
Purpose of the Study:
- To introduce the concept and potential of cancer interception.
- To highlight the role of targeted therapies and immuno-interception.
- To emphasize the need for novel clinical trial and treatment paradigms.
Main Methods:
- Review of recent technological and therapeutic advancements in oncology.
- Analysis of genetic testing and risk stratification methodologies.
- Conceptualization of "immuno-interception" strategies.
Main Results:
- Cancer interception is becoming feasible due to technological progress.
- Targeted therapies and immuno-interception show promise in eliminating premalignant lesions.
- Current clinical trial and treatment frameworks are insufficient for interception strategies.
Conclusions:
- Cancer interception represents a paradigm shift in oncology.
- Novel therapeutic strategies like targeted therapies and immuno-interception are key.
- Distinct clinical approaches are necessary to realize the potential of cancer interception.
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