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Updated: Jun 29, 2025
05:53
Intraoperative Ultrasound in Spinal Surgery
Published on: August 17, 2022
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Mass spectrometry for neurosurgery: Intraoperative support in decision-making
Stanislav I Pekov1,2,3, Denis S Bormotov2, Svetlana I Bocharova2
1Skolkovo Institute of Science and Technology, Moscow, Russian Federation.
Mass Spectrometry Reviews
|April 4, 2024
Summary
Ambient ionization mass spectrometry shows promise for cancer surgery but needs further development for clinical use. This review explores techniques for mass spectrometry-guided brain surgery and implementation challenges.
Area of Science:
- Oncology
- Neurosurgery
- Analytical Chemistry
Background:
- Ambient ionization mass spectrometry (AIM) is a powerful tool for oncological surgery.
- AIM is currently a translational technique, moving from research to clinical application.
- Neurosurgery demands high resection accuracy to balance tumor removal with nerve preservation.
Purpose of the Study:
- To review intraoperative support techniques for oncological neurosurgery.
- To discuss the clinical implementation challenges of mass spectrometry-guided brain surgery.
Main Methods:
- Literature review of intraoperative support techniques in neurosurgery.
- Analysis of mass spectrometry applications in brain tumor resection.
Main Results:
- Several intraoperative support techniques have been developed for neurosurgery.
- Significant hurdles exist in translating AIM to routine clinical practice for brain surgery.
Conclusions:
- Mass spectrometry-guided brain surgery offers potential benefits but requires further development.
- Overcoming translational challenges is crucial for widespread clinical adoption of AIM in neurosurgery.
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