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Published on: February 8, 2018
Progression-free survival is a weakly predictive surrogate end-point for overall survival in follicular lymphoma: A
Charles J Milrod1, Kang Woo Kim2, Christina Raker3
1Department of Hematology/Oncology, Brown University, Providence, Rhode Island, USA.
Abstract:
Although progression-free survival (PFS) is a commonly used surrogate end-point for clinical trials of follicular lymphoma (FL), no analyses have evaluated the strength of surrogacy for PFS with overall survival (OS). A systematic review was performed and 20 studies (total participants, 10 724) met final inclusion criteria. PFS was weakly associated with OS (correlation coefficient; 0.383, p < 0.001). The coefficient of determination was 0.15 (95% CI: 0.002-0.35) suggesting 15% of OS variance could be explained by changes in PFS. This challenges the role for PFS as a surrogate end-point for clinical trials and drug approvals.
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