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Updated: Jun 29, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer

Dorival Mendes Rodrigues-Junior1, Aristidis Moustakas1

  • 1Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Upsala Journal of Medical Sciences
|April 4, 2024
PubMed

Insights

Transforming growth factor beta (TGF-β) signaling influences tumor progression by altering long non-coding RNA (lncRNA) expression. This review details how lncRNAs regulate TGF-β signaling and cancer hallmarks.

Area of Science:

  • Molecular biology
  • Cancer research
  • Genomics

Background:

  • Transforming growth factor beta (TGF-β) signaling is crucial in tumor biology and associated with poor cancer prognosis.
  • TGF-β induces epithelial-to-mesenchymal transition (EMT), promoting cancer spread, stemness, and chemoresistance.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in regulating gene expression and cellular processes.

Purpose of the Study:

  • To review the impact of TGF-β signaling on lncRNA expression.
  • To summarize the regulatory functions of lncRNAs in TGF-β signaling pathways.
  • To explore how these TGF-β-lncRNA networks influence cancer hallmarks.

Main Methods:

  • Literature review and synthesis of existing research on TGF-β signaling and lncRNAs in cancer.
  • Analysis of molecular mechanisms involving SMAD proteins, ubiquitin ligases, and protein kinases in TGF-β pathways.
  • Examination of lncRNA-mediated epigenetic, transcriptional, and post-transcriptional regulation.

Main Results:

  • TGF-β signaling modulates the expression of numerous lncRNAs.
  • lncRNAs act as both suppressors and enhancers of TGF-β signaling.
  • Specific lncRNAs are implicated in regulating key cancer hallmarks like proliferation, migration, and chemoresistance.

Conclusions:

  • The interplay between TGF-β signaling and lncRNAs represents a critical regulatory network in cancer.
  • Targeting TGF-β-regulated lncRNAs offers potential for novel cancer diagnostics and therapeutics.
  • Further research into these molecular mechanisms is essential for developing effective anti-cancer strategies.
Keywords:
Cancerepigeneticsnon-coding RNAsignal transductiontransforming growth factor-β

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