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A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review
Wenpeng Huang1, Zuohuan Zheng2, Zheng Bao1
1Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.
Frontiers in Medicine
|April 4, 2024
Summary
Primary choriocarcinoma in men is rare, presenting with feminization and high beta-hCG. This case highlights aggressive disease despite chemotherapy and pembrolizumab, with a poor prognosis.
Area of Science:
- Oncology
- Endocrinology
- Medical Imaging
Background:
- Non-gestational choriocarcinoma is an extremely rare malignancy in men.
- Clinical signs include gynecomastia, testicular atrophy, and elevated serum human chorionic gonadotropin (β-hCG).
- The condition is characterized by rapid progression and widespread metastatic disease.
Observation:
- A 41-year-old male patient was diagnosed with choriocarcinoma.
- The diagnosis was confirmed by 18F-FDG PET/CT imaging, revealing extensive metastases in the lungs, brain, bone, and retroperitoneal lymph nodes.
- The patient received aggressive chemotherapy combined with pembrolizumab.
Findings:
- Despite aggressive treatment, the patient experienced a poor prognosis.
- Overall survival was limited to 5 months post-diagnosis.
- The case underscores the aggressive nature of this rare cancer.
Implications:
- Non-gestational choriocarcinoma should be considered in young men with gynecomastia and elevated β-hCG levels.
- Comprehensive medical history and systematic examination are crucial for early diagnosis.
- 18F-FDG PET/CT is vital for staging, treatment monitoring, and follow-up of choriocarcinoma.
