Nail Squamous Cell Papilloma: A Rare Case Report

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Squamous cell papilloma is a benign neoplasm.
• Human papillomavirus (HPV) is the primary cause of squamous cell papilloma.
• Nail involvement by squamous cell papilloma has not been previously documented.

Purpose of the Study:

• To present a unique case of squamous cell papilloma affecting the nail.
• To describe the diagnostic and therapeutic approach for this rare condition.
• To contribute to the understanding of nail squamous cell papilloma.

Main Methods:

• A case presentation of a 67-year-old female with a painful, evolving nail lesion.
• Surgical excision of the nail lesion.
• Histopathological examination confirming squamous cell papilloma.
• Adjuvant topical treatment with imiquimod.

Main Results:

• Histopathology confirmed squamous cell papilloma of the nail.
• Surgical excision and imiquimod treatment led to good healing.
• Pain associated with the lesion was effectively controlled.
• The patient experienced a favorable outcome with no recurrence reported.

Conclusions:

• Squamous cell papilloma can occur in the nail apparatus, a previously unreported site.
• A combination of surgical excision and topical imiquimod may be an effective treatment strategy.
• Further research is warranted to establish definitive diagnostic and management guidelines for nail squamous cell papilloma.