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Updated: Jun 29, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Severely obese 14-year-old boy with central sleep apnea several years after head trauma
Yusuke Moritani1, Takumi Shibazaki1, Hotaru Kobori1
1Department of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
Insights
Central sleep apnea (CSA) is uncommon in children but more frequent in obese youth. This case highlights severe obesity as a cause of CSA in a teenager, even with prior neurological injury.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Neurology
Background:
- Central sleep apnea (CSA) is rare in pediatric populations.
- While often linked to neurological conditions like Chiari malformation, CSA prevalence increases significantly in obese children.
- Obesity is typically associated with obstructive sleep apnea, but its role in CSA requires further understanding.
Abstract:
Central sleep apnea (CSA) is rare in older children. Although CSA mostly arises from neurological diseases such as Chiari malformation, the frequency of CSA is significantly higher in obese children. Herein, we describe the case of a 14-yr-old boy who presented with CSA secondary to severe obesity and a history of traumatic lateral medullary syndrome at 8 yr of age. Polysomnography revealed severe sleep apnea syndrome with apnea-hypopnea index of 41.4 per hour and central apnea index of 8.9 per hour. Magnetic resonance imaging of the head showed no new brainstem or cerebellar infarcts; however, old changes in the cerebellar infarction persisted. Obesity is primarily associated with obstructive sleep apnea. However, obesity can result in CSA through pharyngeal collapse and the reduction of oxygen reserves caused by reduced thoracic volume, which suppresses respiratory center stimulation. Because the respiratory center disorder owing to head injury sequelae improved after the acute stage, obesity was deemed the cause of CSA in this case. Hence, children with severe obesity may require CSA monitoring.
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