General pattern of paediatric poisoning in Jordan during 2018-2019

Enas M ALzayadneh1, Kamal A ALHadidi2,3, Ihab Alasasfeh4

  • 1Department of Paediatric, School of Medicine, the University of Jordan, Jordan.

Toxicology Reports
|April 4, 2024
PubMed

Insights

Acute childhood poisoning in Jordan is predominantly caused by medications, affecting young children primarily at home. Caregiver education on safe storage and prompt medical attention are crucial for prevention and management.

Area of Science:

  • Public Health
  • Epidemiology
  • Toxicology

Background:

  • Acute accidental poisoning in children is a global public health concern.
  • Understanding local patterns is vital for effective prevention strategies.

Purpose of the Study:

  • To investigate the epidemiology of acute poisoning in children aged 0-5 years in Jordan.
  • To identify the characteristics and patterns of paediatric poisoning cases.

Main Methods:

  • Retrospective descriptive analysis of data from the National Poison Information Center (NPIC) in Jordan.
  • Data collected over a two-year period (2018-2019).

Main Results:

  • Paediatric poisoning (0-5 years) constituted 88% of all cases.
  • Medication poisoning was the most frequent cause (71.0%).
  • Most poisonings occurred at home (98.7%) and were unintentional (98.6%).

Conclusions:

  • Medications are the leading cause of paediatric poisoning in Jordan.
  • Educating caregivers on safe medication practices is essential.
  • Prompt referral to healthcare facilities is critical in poisoning incidents.
Abstract

Related Concept Videos

Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
820
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
851
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
505
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
3.1K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
971