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Related Concept Videos

Menses Phase01:18

Menses Phase

262
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
262
Proliferative Phase01:20

Proliferative Phase

472
The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
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The Menstrual Cycle01:19

The Menstrual Cycle

803
The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
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Secretory Phase01:19

Secretory Phase

707
The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
707

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Related Experiment Video

Updated: Jun 29, 2025

Establishing a Mouse Model of Thin Endometrium
05:26

Establishing a Mouse Model of Thin Endometrium

Published on: November 1, 2024

676

Walking on thin endometrium.

Baris Ata1,2, Begum Mathyk3, Savci Telek4

  • 1ART Fertility Clinics, Dubai, United Arab Emirates.

Current Opinion in Obstetrics & Gynecology
|April 4, 2024
PubMed
Summary
This summary is machine-generated.

Current assisted reproductive technology protocols often cancel embryo transfers based on endometrial thickness. However, evidence suggests this practice may be unfounded, as thickness alone doesn't reliably predict implantation success.

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Area of Science:

  • Reproductive Endocrinology
  • Infertility Research
  • Ultrasound in Gynecology

Background:

  • Endometrial thickness is a widely used metric in assisted reproductive technology (ART).
  • Current clinical practice often involves canceling embryo transfer if endometrial thickness falls below a predetermined threshold.
  • This dogma is based on the assumption that a thicker endometrium correlates with successful implantation.

Purpose of the Study:

  • To critically evaluate the established dogma regarding endometrial thickness as a predictor of ART success.
  • To investigate the causal relationship between endometrial thickness and embryo implantation.
  • To challenge the current practice of canceling embryo transfers based solely on endometrial thickness.

Main Methods:

  • Review of existing literature on endometrial thickness and ART outcomes.
  • Analysis of methodological limitations in previous studies.
  • Examination of evidence from better-designed studies that do not support specific cut-off values.

Main Results:

  • Methodological limitations in prior research are increasingly acknowledged.
  • Well-designed studies fail to establish a definitive endometrial thickness cut-off for canceling embryo transfers.
  • Ultrasound-measured endometrial thickness may not be a reliable indicator of endometrial receptivity or function.

Conclusions:

  • The reliance on endometrial thickness as a sole predictor for canceling embryo transfers in ART is questionable.
  • Endometrial receptivity is crucial for implantation, but ultrasound thickness is an insufficient marker.
  • Further research is needed to identify more accurate markers of endometrial function and implantation potential.