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Related Experiment Videos

Decrease in HLA-DR-positive monocytes in patients with systemic lupus erythematosus (SLE).

F Shirakawa, U Yamashita, H Suzuki

    Journal of Immunology (Baltimore, Md. : 1950)
    |June 1, 1985
    PubMed
    Summary

    In active Systemic Lupus Erythematosus (SLE), HLA-DR positive monocytes are significantly reduced, impacting immune regulation. These monocyte levels normalize as SLE transitions to an inactive state.

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    Area of Science:

    • Immunology
    • Rheumatology
    • Cell Biology

    Background:

    • Monocytes play a crucial role in immune regulation.
    • Human Leukocyte Antigen - Antigen D Related (HLA-DR) is an important cell surface marker.
    • Aberrant immune responses are characteristic of Systemic Lupus Erythematosus (SLE).

    Purpose of the Study:

    • To investigate the expression of HLA-DR antigens on monocytes in patients with SLE.
    • To correlate HLA-DR positive monocyte levels with SLE disease activity.

    Main Methods:

    • Flow cytofluorometry was used to analyze monocyte populations.
    • Indirect immunofluorescence staining was employed to detect HLA-DR expression on monocytes.

    Main Results:

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  • A marked decrease in both the number and expression of HLA-DR antigens on monocytes was observed in active SLE patients.
  • Monocyte HLA-DR expression and numbers recovered to normal levels in inactive SLE patients.

    • Conclusions:

    • Reduced HLA-DR positive monocytes in active SLE may lead to dysregulated immune responses.
    • The modulation of HLA-DR positive monocytes is implicated in the pathogenesis and progression of SLE.