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Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension
Süleyman Cihan Kara1, Uğur Canpolat1
1Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
Abstract:
Drug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other ARBs, can also cause myopathy. Possible drug-drug interactions should be considered in cases of concomitant prescription of these agents with other myopathic drugs.
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