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Sleep Behaviors and the Shape of Subcortical Brain Structures in Children with Overweight/Obesity: A Cross-Sectional

Cristina Cadenas-Sanchez1,2, Jairo H Migueles3, Lucia V Torres-Lopez3

  • 1Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. cadenas@ugr.es.

Indian Journal of Pediatrics
|April 4, 2024
PubMed

Insights

Children with overweight/obesity who spent more time in bed showed greater expansions in the pallidum and putamen brain regions. This study explored sleep and subcortical brain structure relationships.

Area of Science:

  • Neuroscience
  • Pediatric Health
  • Sleep Science

Background:

  • Childhood obesity is a growing concern with potential impacts on brain development.
  • Understanding the relationship between sleep patterns and brain structure is crucial for pediatric health.

Purpose of the Study:

  • To investigate the association between sleep behaviors and subcortical brain structure morphology in children with overweight/obesity.
  • To utilize a shape analysis approach to identify specific brain regions affected by sleep.

Main Methods:

  • Cross-sectional analysis of 98 children (aged 10.0 ± 1.1 years, 59% boys) with overweight/obesity.
  • Sleep behaviors assessed using wrist-worn accelerometers.
  • Subcortical brain structure shape analyzed via magnetic resonance imaging (MRI) and partial correlation permutation tests.

Main Results:

  • Total time in bed was significantly associated with brain structure.
  • Increased time in bed correlated with greater expansions in the right and left pallidum.
  • More time in bed also linked to expansions in the right putamen.

Conclusions:

  • Findings indicate a relationship between increased time in bed and enlarged pallidum and putamen volumes in overweight/obese children.
  • Suggests that sleep duration may influence subcortical brain development in this population.
Abstract

Keywords:
ActigraphyBrain shapesGrey matterObesitySleep

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