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Pan-Cancer Analysis Identifies BCLAF1 as a Potential Biomarker for Renal Cell Carcinoma

  • 0Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Biochemical Genetics +

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April 4, 2024

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April 4, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

B-cell lymphoma-2-associated transcription factor 1 (BCLAF1) acts as a tumor suppressor in renal cell carcinoma (RCC). High BCLAF1 expression correlates with better prognosis and inhibits RCC cell growth, suggesting its potential as a prognostic marker.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genomics

Background

  • B-cell lymphoma-2-associated transcription factor 1 (BCLAF1) has varied roles in cancer, but its specific function in renal cell carcinoma (RCC) is not well understood.
  • Understanding BCLAF1's impact on tumorigenesis is crucial for identifying new therapeutic targets and prognostic markers.

Purpose Of The Study

  • To investigate the expression, prognostic value, and functional role of BCLAF1 across 33 cancer types, with a focus on renal cell carcinoma (RCC).
  • To determine the correlation of BCLAF1 with clinicopathological features, DNA methylation, and the tumor immune microenvironment in various cancers, particularly RCC.

Main Methods

  • Utilized TCGA and GTEx datasets for comprehensive bioinformatic analysis of BCLAF1 expression, methylation, and prognostic correlations.
  • Conducted in vitro cell biology experiments to assess the functional impact of BCLAF1 on RCC cell proliferation, migration, invasion, apoptosis, and cell cycle.

Main Results

  • BCLAF1 expression was significantly altered in tumor tissues across multiple cancer types and subtypes.
  • In RCC, high BCLAF1 expression was associated with improved patient prognosis and correlated with stage, gender, and histological grade.
  • BCLAF1 demonstrated tumor-suppressive functions in RCC cells, inhibiting proliferation and invasion while promoting apoptosis and cell cycle arrest.

Conclusions

  • BCLAF1 plays a significant role in tumorigenesis, acting as a tumor suppressor particularly in renal cell carcinoma (RCC).
  • BCLAF1 exhibits potential as a valuable prognostic biomarker for renal cell carcinoma (RCC).
  • Further research into BCLAF1's regulatory mechanisms could unveil novel therapeutic strategies for RCC.

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