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YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus

Danhong Dong1, Jiangpeng Wei1, Weidong Wang1

  • 1Department of Gastrointestinal Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China.

Cell Biology and Toxicology
|April 4, 2024
PubMed

Insights

Regulator of differentiation 1 (ROD1) promotes gastric cancer (GC) growth and spread by altering oncogene and tumor suppressor levels. The YTHDC1 protein enhances this by increasing ROD1 in the nucleus, driving GC progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • RNA-binding proteins (RBPs) significantly impact tumor progression and are potential therapeutic targets.
  • Regulator of differentiation 1 (ROD1), an RBP and splicing factor, is abnormally expressed in tumors, but its role in gastric cancer (GC) remains unclear.

Purpose of the Study:

  • To elucidate the mechanism of ROD1 involvement in gastric cancer (GC) development.
  • To investigate the role of YTHDC1 in regulating ROD1 function in GC.

Main Methods:

  • In vitro experiments to assess GC cell proliferation and metastasis.
  • Analysis of gene expression levels of OIP5 and GPD1L.
  • Investigation of the interaction between YTHDC1 and ROD1.
  • Assessment of ROD1 nuclear enrichment.

Main Results:

  • ROD1 significantly stimulates GC cell proliferation and metastasis, correlating with poor patient prognosis.
  • ROD1 modulates the expression balance between the oncogene OIP5 and the tumor suppressor GPD1L in GC.
  • YTHDC1 interacts with ROD1 and promotes its nuclear enrichment, thereby regulating OIP5/GPD1L expression.

Conclusions:

  • ROD1 promotes GC progression by disrupting the OIP5/GPD1L balance.
  • YTHDC1 enhances GC development by increasing nuclear ROD1 levels, highlighting a novel regulatory pathway.
Keywords:
Alternative splicingGastric cancerN6-methyladenosineRNA-binding proteins

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