Three new pterosins from Pteris semipinnata.

Area of Science:

• Natural Product Chemistry
• Pharmacology
• Phytochemistry

Background:

• Pteris semipinnata is a plant species known to contain various bioactive compounds.
• Pterosins are a class of natural products with diverse biological activities.
• Understanding the chemical constituents and pharmacological properties of medicinal plants is crucial for drug discovery.

Purpose of the Study:

• To isolate and characterize new pterosins from Pteris semipinnata.
• To evaluate the anti-inflammatory potential of the isolated novel pterosins.
• To report the first isolation of specific known pterosins from this plant.

Main Methods:

• Isolation of compounds using chromatographic techniques.
• Structure elucidation employing High-Resolution Electrospray Ionization Mass Spectrometry (HRESIMS), Nuclear Magnetic Resonance (NMR) spectroscopy, and Circular Dichroism (CD).
• Assessment of anti-inflammatory activity through inhibition of Nuclear Factor-kappa B (NF-κB) induction.

Main Results:

• Three new pterosins, semipterosin A (1), B (2), and C (3), were identified.
• Eleven known pterosins (4-14) were also isolated, with compounds 6-14 reported for the first time from this plant.
• Compounds 1-3 demonstrated significant inhibition of NF-κB induction, with percentages of 40.7%, 61.9%, and 34.0%, respectively.

Conclusions:

• The chemical investigation of Pteris semipinnata yielded three novel pterosins and eleven known ones.
• The newly isolated pterosins possess notable anti-inflammatory activity, indicated by their ability to inhibit NF-κB.
• This research contributes to the understanding of Pteris semipinnata's chemical diversity and therapeutic potential.