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Peripheral helper T cells in human diseases

Xueyang Zou1, Feifei Huo2, Lulu Sun1

  • 1Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, 130000, PR China.

Journal of Autoimmunity
|April 4, 2024
PubMed

Peripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral blood, Tph cells can also be identified. The aberrant proliferation and functions of Tph cells are commonly found in the patients with disease. In this review, first we will summarize the biological characteristics of Tph cells, such as the expression of surface molecules, transcription factors and cytokines, and discuss its B cell help functions. Tph cells also have roles in a wide range of human diseases, including autoimmune diseases, infectious diseases, malignancies etc. Therefore, there is a strong interest in targeting Tph cells to improve treat strategies of human diseases.

Keywords:
Autoimmune diseasesB cellsInfectious diseasesInterleukin-21MalignanciesPeripheral helper T cells

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