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Brain-Heart Axis and the Inflammatory Response: Connecting Stroke and Cardiac Dysfunction

Xiaosheng Chen1, Jiajie Gu1, Xiaojia Zhang1

  • 1Department of Neurosurgery, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

Cardiology
|April 4, 2024
PubMed

Insights

Stroke can significantly impact heart function, leading to cardiac dysfunction. Understanding the brain-heart axis mechanisms post-stroke is crucial for improving patient outcomes and reducing mortality.

Area of Science:

  • Neuroscience
  • Cardiology
  • Pathophysiology

Background:

  • The brain-heart axis, detailing interactions between brain injuries and cardiac dysfunction, is increasingly studied.
  • Brain injuries are a primary cause of post-stroke mortality, with cardiac dysfunction being the second leading cause.

Purpose of the Study:

  • To review the mechanisms and effects of cardiac dysfunction following stroke (ischemic or hemorrhagic).
  • To elucidate the influence of stroke on the heart and understand the underlying brain-heart axis mechanisms.

Main Methods:

  • Literature review focusing on mechanistic interactions between brain and heart post-stroke.
  • Analysis of studies investigating cardiac dysfunction after stroke onset.

Main Results:

  • Established association between brain injuries and cardiac dysfunction.
  • Identified stroke site and brain-heart axis mechanisms (e.g., HPA axis, immune responses) as key factors.

Conclusions:

  • Cardiac dysfunction is a significant consequence of stroke, necessitating further research.
  • Understanding the brain-heart axis is vital for managing stroke and associated cardiac complications.
Abstract

Keywords:
Brain-heart axisCardiac dysfunctionInflammationStroke

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