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Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus.

Cristina Concetti1, Paulius Viskaitis1, Nikola Grujic1

  • 1Department of Health Sciences and Technology, Neuroscience Center Zürich (ZNZ), Swiss Federal Institute of Technology (ETH Zürich), Zürich 8092, Switzerland.

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Summary

Researchers identified a neural circuit controlling information-seeking behavior in mice. Melanin-concentrating hormone neurons (MCH) and locus ceruleus noradrenaline cells were found to regulate unsupported rearing, a key behavior for seeking information.

Keywords:
explorationhypothalamusinnate behaviorlocus ceruleusmelanin-concentrating hormonerearing

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Area of Science:

  • Neuroscience
  • Animal Behavior
  • Cognitive Science

Background:

  • Information seeking is crucial for survival across species.
  • Unsupported rearing in rodents is a model for studying cognition and neuropsychiatric states.
  • Neural mechanisms underlying information-seeking behavior are not well understood.

Purpose of the Study:

  • To investigate the neural signals and circuits controlling unsupported rearing behavior in mice.
  • To explore the role of melanin-concentrating hormone neurons (MCH) in information seeking.
  • To understand the interaction between MCH neurons and stress-related brain centers.

Main Methods:

  • Recording neural activity of MCH neurons during spontaneous behaviors in mice.
  • Utilizing loss and gain of function analyses to determine the causal role of MCH neurons and MCHR1 receptors.
  • Investigating the influence of locus ceruleus noradrenaline cells on MCH neuron activity and rearing behavior.

Main Results:

  • Large spikes in MCH neuron activity were observed to align with unsupported rearing events.
  • MCH neurons and MCHR1 receptors were found to specifically control the frequency and duration of rearing.
  • Activity in locus ceruleus noradrenaline cells rapidly inhibited MCH neurons, modulating rearing behavior.

Conclusions:

  • A specific neural module involving MCH neurons and locus ceruleus has been identified that tracks and controls information-seeking behavior (rearing).
  • These findings provide insights into the neurobiology of information seeking and may inform preclinical models of neuropsychiatric disorders.
  • The study highlights the role of MCH signaling in regulating motivated behaviors.